Author ORCID Identifier
0009-0003-8522-538X
Abstract
Despite the high mortality rate involved with invasive cerebral mycoses, there is a relative lack of research available around antifungals capable of crossing the blood brain barrier.
In this study the metabolites of four plants (Crocus vernus, Miniature Narcissus (daffodil), Osmanthus delavayi and Taraxacum officinale (common dandelion)) and two bacteria (Lacticaseibacillus paracasei and Staphylococcus epidermidis) were extracted and assayed for antifungal activity against Candida albicans and Saccharomyces cerevisiae. Thin layer chromatography and bioautography were then employed to assess the activity of the constituent components of sources showing antifungal activity.
Metabolites of S.epidermidis, and extracts of miniature Narcissus and Taraxacum officinal demonstrated no antifungal activity, metabolites of Lacticaseibacillus paracasei demonstrated variable antifungal activity and extracts of Osmanthus delavayi demonstrated previously unreported antifungal activity, although there were issues with repeatability.
Osmanthus delavayi warrants further study, with an aim to separate out each component, test it for bioactivity and/or asses for the presence of synergism between two or more components, determine their interactions with the blood brain barrier and any potential toxicities and therefore assess the therapeutic potential.
Recommended Citation
Peacock, Hannah Mai and O'Connor, James Anthony
(2023)
"Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses.,"
SURE Journal: Science Undergraduate Research Experience Journal:
Vol. 5:
Iss.
1, Article 3.
doi:https://doi.org/10.21427/45q2-g772
Available at:
https://arrow.tudublin.ie/sure_j/vol5/iss1/3
DOI
https://doi.org/10.21427/45q2-g772
Creative Commons License
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Bacterial Infections and Mycoses Commons, Life Sciences Commons, Nervous System Diseases Commons, Other Chemicals and Drugs Commons, Other Pharmacy and Pharmaceutical Sciences Commons