Document Type

Doctoral Thesis

Disciplines

3. MEDICAL AND HEALTH SCIENCES, Oncology

Publication Details

Submitted by Kate Byrne, BSc (Hons.) Doctor of Philosophy Food Science and Environmental Health, Environmental Sustainability and Health Institute, Technological University Dublin.

Abstract

Glioblastoma (GBM) is the most common and aggressive malignant grade IV brain tumour. It remains an incurable disease whereby the median survival rate is 15 months and 5.5 % of all patients survive five years post diagnosis. The current therapeutic strategies include the use of maximal safe surgical resection, radiotherapy, and the use of the gold standard chemotherapeutic, Temozolomide (TMZ), which is referred to as the “Stupp Protocol”. Earlier research identified two compounds, which are structurally different but exhibit a similar biological effect to Metformin, the first in-line treatment for type II diabetes. Combining drugs which target cell metabolism such as Metformin with chemotherapeutic agents and or radiotherapy has become an attractive treatment for cancer. It was hypothesized that these compounds may have anti-cancer properties due to their ability to impede cell metabolism.

DOI

https://doi.org/10.21427/wqkn-7f57

Creative Commons License

Creative Commons Attribution-Share Alike 4.0 International License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 International License.

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