ORCID
- Shengxin Zhang: 0000-0001-6945-2521
- Tao Zhang: 0000-0003-1079-5364
- Gemma Kinsella: 0000-0002-6329-5841
- James Curtin: 0000-0002-9320-9254
Abstract
The standard treatments for prostate cancer (PCa) include chemotherapy, hormone therapy, targeted therapies based on androgen receptor (AR) and/or gonadotropin-releasing hormone (GnRH) receptor antagonists, and radiation therapy. But PCa therapeutic resistance remains an unsolved challenge, leading to progression to castration-resistant prostate cancer (CRPC). Emerging PCa therapies – including poly(ADP-ribose) polymerase (PARP) inhibitors, AR crosstalk signalling pathway inhibitors, B-cell lymphoma 2 (BCL-2) inhibitors, cyclin-dependent kinase 4 (CDK4)/CDK6 inhibitors, CRISPR/Cas9, epigenetic inhibitors, and nanotechnology-based drug-delivery approaches – provide promising targeted solutions. Targeted protein degradation therapy, particularly AR degradation therapies, effectively inhibits resistance at its source. This review summarises the established and emerging PCa therapies, focusing on discussing their efficacy in terms of PCa resistance with supporting experimental findings and the mechanisms of PCa drug resistance.
Keywords
castration-resistantprostatecancer;drugresistance;prostatecancertherapy;prostatecancerclinicalresearch
Publication Date
2025-01-01
Publication Title
Drug Discovery Today
ISSN
1359-6446
Deposit Date
2025-07-28
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Recommended Citation
Zhang, Shengxin; Zhang, Tao; Kinsella, Gemma; and Curtin, James, "A review of the efficacy of prostate cancer therapies against castration-resistant prostate cancer" (2025). Research Outputs: 2025-Present. 45.
https://arrow.tudublin.ie/schfsehro/45