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Journal of Academic Research and Innovation

Abstract

Urchin-like gold nanoparticles have shown to enhance cytotoxicity against cancer cells compared to original gold nanoparticles making them a ‘promise’ for cancer treatment because of their specific size inducing more hot spots and produced surface/volume ratio. Different concentrations of urchin-like gold nanoparticles can be synthesised to observe the different effects the particles pose against the cancer cells. Urchin-like AuNPs were synthesised using the chemical reduction method to synthesise gold nano seeds. Hydroquinone was used to create the urchin shape of the gold nanoparticles. In vitro, cytotoxicity studies were performed to observe which concentration of urchin-like AuNPs had a stronger cytotoxicity against the U-373 and Caco-2 cancer cell lines. The Urchin-like AuNPs enhanced their cytotoxic properties against the cancer cell lines which affected the cell viability and proliferation which was analyzed using the MTT assay. The Urchin-like AuNPs (100μl hydroquinone) dose at 15μl had the highest cytotoxicity compared to the 5 and 10μl, the viability of the 15μl was at 60% which was the highest. The Urchin-like AuNPs presented a stronger cytotoxicity against the colorectal cells than the glioblastoma cells due to their structure. The glioblastoma cells could be more complex in structure and may require a stronger dose of Urchin-like gold nanoparticles.

Creative Commons License

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

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