Conformational Studies of Gram-Negative Bacterial Quorum Sensing Acyl Homoserine Lactone (AHL) Molecules: the Importance of the n→* Interaction

Authors

Fintan Kelleher, Technological University DublinFollow
Goar Sánchez-Sanz
Darren Crowe
Alan Nicholson
Adrienne Fleming

Document Type

Article

Rights

Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Disciplines

Organic Chemistry, Physical chemistry

Publication Details

Biophysical Chemistry, Volume 238, July 2018, Pages 16-21.

https://0-www.sciencedirect.com.ditlib.dit.ie/journal/biophysical-chemistry

Abstract

A ¹H NMR study shows the presence of intermolecular hydrogen bonds for AHLs in CDCl₃ solution. A detailed computational study of the structure of AHLs and the relative stability between the extended conformations (X) and those showing n→p* interactions (np) have been carried out by means of DFT calculations. Solvent effects have been shown to be very important when stabilising np conformations, particularly with polar solvents. This was shown by the shortening of C···O intramolecular distances and the increase in the relative energies favouring the np conformation with the dielectric constant of the solvent. The charge transfer between the O donor and the acceptor carbonyl group, assessed by second order perturbation energies, E(2), also shows an increase in the E(2) values with the dielectric constant of the solvent.

DOI

https://doi.org/10.1016/j.bpc.2018.04.002

Recommended Citation

Kelleher, F. et al. (2018) Conformational studies of Gram-negative bacterial quorum sensing acyl homoserine lactone (AHL) molecules: the importance of the n→* interaction. Biophysical Chemistry, Volume 238, July 2018, Pages 16-21. doi:10.1016/j.bpc.2018.04.002