Author ORCID Identifier
0000-0002-8784-2109
Document Type
Book Chapter
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
3. MEDICAL AND HEALTH SCIENCES
Abstract
The advent of recanalization therapies has transformed the management of acute ischemic stroke patients. The timing of symptom onset is one of the key criteria for selecting the recanalization method as pharmacological and non- pharmacological recanalization therapies are only safe when administered within strict, but evolving, time windows. Magnetic resonance imaging (MRI) reveals ischemia within minutes and estimates ischemia duration in brain parenchyma. Preclinical studies have shown that by combining diffusion and relaxometric MRI, timing ischemic strokes is possible with clinically acceptable accuracy. MRI-based stroke timing techniques have been adopted in stroke clinics to stratify patients with unknown onset time for intravenous thrombolysis, resulting in improved outcomes in clinical trials. More recent MRI approaches use absolute apparent diffusion coefficient (ADC) and T2 relaxation time data in a user-independent manner to estimate the stroke onset time in absolute terms. The introduction of expedited MRI acquisition protocols has made MRI a fast neurodiagnosis modality. Exploiting advanced technologies such as Magnetic Resonance Fingerprinting (MRF), artificial intelligence (AI), and machine learning (ML) for the post-processing of MRI data, combined with fast MRI techniques, is expected to speed up the translation of objective stroke timing procedures into patient management.
DOI
https://doi.org/10.36255/exonpublications.stroke.timingischemicstroke.2021
Recommended Citation
McGarry, Bryony and Kauppinen, Risto, "Timing the Ischemic Stroke by Multiparametric Quantitative Magnetic Resonance Imaging" (2021). Books/Book Chapters. 29.
https://arrow.tudublin.ie/totalarcscbk/29
Funder
No funding was received for this work.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 International License.
Publication Details
https://pubmed.ncbi.nlm.nih.gov/34279887/
https://doi.org/10.36255/exonpublications.stroke.timingischemicstroke.2021