ORCID
- George Amarandei: 0000-0002-6648-6635
Abstract
Cationic amphipathic poly(ethylene glycol)-based polymers are generated with synthetic efficiencies allowing their evaluation as antimicrobial peptide (AMP) mimetics. Accordingly, statistical copolymers with cationic units consistently functionalized with guanyl groups, but different side-chain lengths, and hydrophobic units displaying long aliphatic, branched, and/or aromatic side chains are produced and tested for their antimicrobial and hemolytic properties. The results obtained indicate that candidates with activities and selectivity commensurate to some AMPs can be obtained and that further development of this novel type of antimicrobial peptidomimetics, pegtides, is warranted for clinical and/or biotechnological applications.
Keywords
antimicrobial peptides, cationic amphipathic copolymers, functionalized poly(ethylene glycol), pegtides, peptidomimetics
DOI Link
Publication Date
2025-11-08
Publication Title
ChemBioChem
Volume
26
Issue
21
ISSN
1439-4227
Deposit Date
2026-10-29
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Additional Links
Recommended Citation
Shine, C., Connolly, J., Murphy, R., Lafferty, H., Alfnikh, A., Buijs, N., Shahrour, H., Martin, N., O'Neill, E., Amarandei, G., Muldoon, J., Maresca, M., Fitzgerald-Hughes, D., & Devocelle, M. (2025) 'Poly(ethylene Glycol)-Based Peptidomimetics (Pegtides) of Antimicrobial Peptides', ChemBioChem, 26(21). Available at: 10.1002/cbic.202500258