Switch-on Luminescent Sensing of Unlabelled Bacterial Lectin by Terbium(iii) Glycoconjugate Systems

Authors

Karolina Wojtczak, University of Galway, Ireland
Eva Zahorska, Helmholtz Centre for Infection Research, Germany
Ian J. Murphy, University of Galway, Ireland
Finnja Koppel, Technological University Dublin, IrelandFollow
Gordon Cooke, Technological University DublinFollow
Alexander Titz, Helmholtz Centre for Infection Research, Germany
Joseph P. Byrne, University College Dublin, Ireland

Document Type

Article

Disciplines

1.4 CHEMICAL SCIENCES

Publication Details

https://pubs.rsc.org/en/content/articlelanding/2023/CC/D3CC02300A

Wojtczak, K., Zahorska, E. & Murphy, I.J. (2023). Switch-on luminescent sensing of unlabelled bacterial lectin by terbium (III) glycoconjugate systems. Chemical Communications, vol. 59, no. 8384.

https://doi.org/10.1039/d3cc02300a

Abstract

Interactions of lectins with glycoconjugate-terbium(III) self-assembly complexes lead to sensing through enhanced lanthanide luminescence. This glycan-directed sensing paradigm detects an unlabelled lectin (LecA) associated with pathogen P. aeruginosa in solution, without any bactericidal activity. Further development of these probes could have potential as a diagnostic tool.

DOI

https://doi.org/10.1039/d3cc02300a

Recommended Citation

Wojtczak, Karolina; Zahorska, Eva; Murphy, Ian J.; Koppel, Finnja; Cooke, Gordon; Titz, Alexander; and Byrne, Joseph P., "Switch-on Luminescent Sensing of Unlabelled Bacterial Lectin by Terbium(iii) Glycoconjugate Systems" (2023). Articles. 142.
https://arrow.tudublin.ie/scschcpsart/142

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