Author ORCID Identifier

ttps://orcid.org/0009-0005-3820-4695

Document Type

Technical Report

Disciplines

Applied mathematics, Computer Sciences, Behavioural sciences biology, Infectious diseases, Epidemiology

Publication Details

This  is an ODD (technical) document that has not been published. It is aimed at facilitating the reproduction and extension of an agent based model that extended a baseline homogeneous model of hepatitis c virus transmission among people who inject drugs.

The baseline model (M1) that was extended in this model is described in Ale et al., 2026, https://doi.org/10.21427/810p-ke33

Abstract

The model described in this ODD is an agent-based model of hepatitis C virus (HCV) transmission among people who inject drugs (PWID). The model extended a baseline homogeneous model by incorporating structural heterogeneity via a two-group interaction framework. The syringe-sharing population in the model is divided into inner and outer circle groups representing individuals with differing levels of syringe-sharing interaction intensity. While all agents share the same syringe-sharing probability and epidemiological processes remain identical across agents, the number of daily interaction opportunities differs between the two groups. Interactions in the model are generated dynamically using proximity-based sampling at each timestep (one day), allowing agents to form syringe-sharing interactions based on spatial closeness. Transmission occurs through direct syringe-sharing events, with infection probability determined by accumulated daily exposure to infectious partners. The model tracks transitions between susceptible, chronic infection, treatment initiation, cure, and resistance states, and is calibrated to Irish HCV surveillance data. This model serves to examine how introducing structural heterogeneity in interaction intensity influences epidemic dynamics relative to the homogeneous baseline model.

DOI

https://doi.org/10.21427/6r9q-4928

Funder

Technological University

Creative Commons License

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

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