Document Type
Review
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
Biochemistry and molecular biology
Abstract
Peroxisomes are single membrane bound organelles present in almost all eukaryotic cells, and to date have been shown to contain approximately 60 identified enzymes involved in various metabolic pathways, including the oxidation of a variety of lipids. These lipids include very long-chain fatty acids, methyl branched fatty acids, prostaglandins, bile acid precursors, and xenobiotics that are either β-oxidized or α-oxidized in peroxisomes. The recent identification of several acyl-CoA thioesterases and acyltransferases in peroxisomes has revealed their various functions in acting as auxiliary enzymes in α- and β-oxidation in this organelle. To date, 9 functional acyl-CoA thioesterases and acyltransferases have been identified in mouse and 4 functional acyl-CoA thioesterases and acyltransferases in human, thus these enzymes make up a substantial portion of peroxisomal proteins. This review will therefore focus on new and emerging roles for these enzymes in assisting with the oxidation of various lipids, amidation of lipids for excretion from peroxisomes, and in controlling coenzyme A levels in peroxisomes.
DOI
https://doi.org/10.1016/j.plipres.2008.05.001
Recommended Citation
Hunt, M., Alexson, S. (2008) Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism. Progress in Lipid Research - 47(2008) 405-421. doi:10.1016/j.plipres.2008.05.001
Included in
Biochemistry Commons, Bioinformatics Commons, Congenital, Hereditary, and Neonatal Diseases and Abnormalities Commons, Molecular Biology Commons, Nutritional and Metabolic Diseases Commons
Publication Details
Progress in Lipid Research - 47(2008) 405-421