Document Type
Article
Abstract
Objective: To examine the association between maternal metabolic parameters in pregnancy and growth trajectories up to 5 years of age. Methods: Data from mother–child pairs who participated in the ROLO study, a randomized trial examining the impact of a low glycaemic index diet on the recurrence of macrosomia, were analysed. Fetal and child growth trajectories were developed from longitudinal measurements from 20 weeks gestation up to 5 years of age. We examined associations between maternal fasting glucose, insulin, HOMA-IR and leptin, taken in early pregnancy (14–16 weeks) and late pregnancy (28 weeks), and weight (kg) and abdominal circumference (cm) trajectories using linear spline multilevel models. Results: We found no strong evidence of associations between any maternal metabolic parameters and fetal to childhood weight and abdominal circumference trajectories from 20 weeks gestation to 5 years. Conclusion: In a cohort of women with obesity with infants at risk of macrosomia, maternal metabolic markers were not strongly associated with trajectories of weight or abdominal circumference from 20 weeks gestation to 5 years of age.
DOI
10.1111/ijpo.12976
Recommended Citation
Bartels, H. C., O'Keeffe, L. M., Yelverton, C. A., O'Neill, K. N., Geraghty, A. A., O'Brien, E. C., Killeen, S. L., McDonnell, C., & McAuliffe, F. M. (2023). Associations between maternal metabolic parameters during pregnancy and fetal and child growth trajectories from 20 weeks' gestation to 5 years of age. Pediatric Obesity, 18(1), Article e12976. https://doi.org/10.1111/ijpo.12976
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Details
https://doi.org/10.1111/ijpo.12976