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1.6 BIOLOGICAL SCIENCES
FAS-associated protein with death domain (FADD) is a major adaptor protein involved in extrinsic apoptosis, embryogenesis, and lymphocyte homeostasis. Although abnormalities of the FADD/death receptor apoptotic pathways have been established in tumorigenesis, fewer studies have analyzed the expression and role of phosphorylated FADD (pFADD). Our identification of FADD as a lymphoma-associated autoantigen in T-cell lymphoma patients raises the possibility that pFADD, with its correlation with cell cycle, may possess role(s) in human T-cell lymphoma development. This immunohistochemical study investigated pFADD protein expression in a range of normal tissues and lymphomas, particularly T-cell lymphomas that require improved therapies. Whereas pFADD was expressed only in scattered normal T cells, it was detected at high levels in T-cell lymphomas (eg, 84% anaplastic large cell lymphoma and 65% peripheral T cell lymphomas, not otherwise specified). The increased expression of pFADD supports further study of its clinical relevance and role in lymphomagenesis, highlighting phosphorylation of FADD as a potential therapeutic target.
Patel, S. et al (2014). Increased expression of phosphorylated FADD in anaplastic large cell and other T-Cell lymphomas.Biomark Insights, 9, pp.77-84. doi:10.4137/BMI.S16553
Julian Starmer-Smith Lymphoma Fund, Leukaemia & Lymphoma Research, Sam Foye Fund, National Institute for Health Research (NIHR) Oxford Biomedical Research Center Programme, and the Science Foundation Ireland and Enterprise Ireland (PC/2007/193)