Document Type
Theses, Masters
Disciplines
3. MEDICAL AND HEALTH SCIENCES, 3.3 HEALTH SCIENCES
Abstract
Human Papillomavirus (HPV) is the most diagnosed sexually transmitted infection (STI) in the world and high risk (HR-HPV) types are associated with 96% of cervical cancer cases. Cervical cancer is the fourth leading cause of cancer death amongst women and screening for cervical cancer has led to a 70% reduction in deaths. Medical professionals currently use the HPV vaccine and screening to prevent the spread of HPV and to diagnose precancerous lesions in the cervix before they develop to late grade cancer. The World Health Organisation (WHO) recommends that HPV testing be used as a primary screening method as a positive HR-HPV result is indicative of cervical cancer risk. However, the tests currently available are not specific enough as they can only detect HR-HPV types; they cannot distinguish between them. None of the HPV assays which are currently commercially available have used the E1 gene as a target for molecular detection. This project aims to investigate the use of the E1 gene as a target for molecular detection and differentiation of multiple HR-HPV types.
DOI
https://doi.org/10.21427/DVP3-PP57
Recommended Citation
Reina, Shannon, "An investigation into the use of the E1 gene as a target gene for molecular detection and differentiation of HR-HPV types" (2026). Masters. 121.
https://arrow.tudublin.ie/scienmas/121
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