Raman Microspectroscopy for Detection of Oral Potentially Malignant Disorders Using Minimally Invasive Brush Biopsy Samples

Authors

Isha Behl, Technological University DublinFollow

Document Type

Theses, Ph.D

Disciplines

3.3 HEALTH SCIENCES

Publication Details

submitted for the award of Doctor of Philosophy, Technological University Dublin. 202.

doi:10.21427/6gf3-8663

Abstract

Oral cancer is one of the most common cancers worldwide. The current gold standard for screening and diagnosis of oral premalignant and cancerous lesions is histopathological examination. Subjectivity is a major limitation of this technique, however. Other diagnostic methods exist, but they are not sensitive enough for early detection of potentially malignant disorders (PMDs), as these methods are based on morphological changes, which can occur late in malignant transformation. Raman spectroscopy, on the other hand, can provide molecular level information of the biological sample, through unique vibrational fingerprints of molecules. This is advantageous over the gold standard method, as molecular changes can precede morphological changes.

DOI

https://doi.org/10.21427/6gf3-8663

Recommended Citation

Behl, Isha, "Raman Microspectroscopy for Detection of Oral Potentially Malignant Disorders Using Minimally Invasive Brush Biopsy Samples" (2024). Doctoral. 275.
https://arrow.tudublin.ie/sciendoc/275

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.