Author ORCID Identifier
Document Type
Other
Disciplines
Cell biology,, Biochemistry and molecular biology
Abstract
Androgen receptor (AR)-targeted therapy remains the gold standard strategy for the treatment of advanced prostate cancer. Several compounds of Indane derivatives have been reported to exhibit significant AR antagonist capabilities, starting at a concentration as low as 0.1 μM. However, an anti-prostate cancer lead molecule derived from Indane-related scaffold remains elusive. The project will investigate the interaction of novel bioactive indane scaffolds as androgen receptor antagonists through in silico and in vitro screening to complete the hit-to-lead, while also investigating potential drug delivery and drug activation/sensitisation mechanisms using a combination of colloid nanomaterial and cold atmospheric plasma to target AR-independent, recurrent prostate cancer.
DOI
https://doi.org/10.21427/xs9d-en93
Recommended Citation
Zhang, Shengxin; Curtin, James F.; Kinsella, Gemma K; and Zhang, Tao, "Exploration of the Activity, Delivery and Activation of Androgen Receptor Potential Indane Scaffold Antagonists for Prostate Cancer Treatment" (2024). Other resources. 32.
https://arrow.tudublin.ie/schfsehoth/32
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Publication Details
School of Food Science & Environmental Health (FSEH) research event 2024 (TU Dublin)
doi:10.21427/xs9d-en93