Modulation of Gut Microbiota by Bioactive Compounds for Prevention and Management of Type 2 Diabetes
Document Type
Article
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
3. MEDICAL AND HEALTH SCIENCES
Abstract
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM.
DOI
https://doi.org/10.1016/j.biopha.2022.113148
Recommended Citation
Rabina Sharma, B., Jaiswal, S. & Ravindra, P.V. (2020). Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes. Biomedicine & Pharmacotherapy, vol. 152, no. 113148. doi:10.1016/j.biopha.2022.113148
Funder
Department of Biotechnology (DBT), and Science and Engineering Research Board (SERB), Govt. of India