Document Type
Article
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
1.6 BIOLOGICAL SCIENCES
Abstract
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumour in adults. Treatments include surgical resection, radiotherapy, and chemotherapy. Despite this, the prognosis remains poor, with an impacted quality of life during treatment coupled with brain tumour recurrence; thus, new treatments are desperately needed. In this review, we focus on recent advances in G-protein-coupled receptor (GPCR) targets. To date, the most promising targets are the chemokine, cannabinoid, and dopamine receptors, but future work should further examine the melanocortin receptor-4 (MC4R), adhesion, lysophosphatidic acid (LPA) and smoothened (Smo) receptors to initiate new drug-screening strategies and targeted delivery of safe and effective GBM therapies.
DOI
https://doi.org/10.1016/j.drudis.2021.07.008
Recommended Citation
Byrne KF et al. (2021) G-protein-coupled receptors as therapeutic targets for glioblastoma. Drug Discov Today. 2021 Jul 14:S1359-6446(21)00315-9. doi: 10.1016/j.drudis.2021.07.008. Epub ahead of print. PMID: 34271165.
Funder
TU Dublin