Erratum: Antidiabetic Activities of an LC/MS Fingerprinted Aqueous Extract of Fagonia Cretica L. In Preclinical Models

Authors

Imran Nazir, The Islamia University of Bahawalpur, Pakistan
Nisar Ur Rahman, COMSATS Institute of Information Technology, Pakistan
Zunaira Alvi, The Islamia University of Bahawalpur, Pakistan
M Hafizur Rahman, University of Karachi, Pakistan
Jandirk Sendker, University of Münster, Institute of Pharmaceutical Biology and Phytochemistry, Germany.
Tao Zhang, Technological University DublinFollow
Neil Frankish, Trinity College Dublin, Ireland
Helen Sheridan, Trinity College Dublin, Ireland

Document Type

Article

Rights

Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Disciplines

1.4 CHEMICAL SCIENCES, 1.6 BIOLOGICAL SCIENCES, 3. MEDICAL AND HEALTH SCIENCES

Publication Details

Planta Medica

Abstract

Diabetes mellitus is a chronic disease and one of the most important public health challenges facing mankind. Fagonia cretica is a medicinal plant used widely in the Punjab in Pakistan. A recent survey has demonstrated that traditional healers and herbalists frequently use this plant to treat diabetes. In the current study the traditional medicine was prepared as a tea and the profile of the main metabolites present in the TM, was analysed via LC/MS/MS. The extract was shown to contain a number of phenolic glycosides including quercetin-3-O-rutinoside, kaempferol-3-rutnoside, kaempferol-3-O-glycoside, kaempferol-3(6'-malonylglucoside), isorhamnetin-3-O-rutinoside, and isorhamnetin 3-(6''-malonyglucoside) in addtional to two unidenntified sulphonated saponins. The traditional medicine inhibits α-glucosidase in vitro with an IC₅₀ of 4.62 µg/ml. The hypoglycaemic effect of the traditional medicine was evaluated in normoglycaemic and streptozotocin-treated diabetic rats, using glibenclamide as internal control. The preparation (250 or 500 mg/kg body weight) was administered once a Day for 21consecutive Days. The dose of 500 mg/kg was effective in the management of the disease causing a 45% decrease in plasma glucose level at the end of the experimental period. Histological analysis of pancreatic sections confirmed that streptozotocin/nictotinamide treatment caused destruction of pancreatic islet cells while pancreatic sections from treatment groups showed that both the extract and glibenclamide partially prevented this deterioration. The mechanism of this protective effect is unclear. However, such a finding suggests that ingestion of the tea could confer additional benefits and should be investigated further.

DOI

10.1055/s-0043-109620

Recommended Citation

Nazir I., Rahman N., Alvi Z., Rahman H., Sendker J., Zhang T., Frankish N., Sheridan H. (2017). Erratum: Antidiabetic activities of an LC/MS fingerprinted aqueous extract of Fagonia cretica L. in preclinical models. Planta Medica, 83, E3.