Novel Mast Cell-Stabilising Amine Derivatives of 3,4 Dihydronaphthalen-1(2H)-One and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-5-one

Authors

James W. Barlow, University of Dublin, Trinity College
Tao Zhang, Technological University DublinFollow
Orla Woods, University of Dublin, Trinity College
Adam J. Byrne, University of Dublin, Trinity College
John J. Walsh, University of Dublin, Trinity College

Document Type

Article

Rights

Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Disciplines

1.4 CHEMICAL SCIENCES, 1.6 BIOLOGICAL SCIENCES, 3. MEDICAL AND HEALTH SCIENCES

Publication Details

Medicinal Chemistry

Abstract

In an investigation of 4-amino-3,4-dihydronaphthalen-1(2H)-ones as novel modulators of allergic and inflammatory phenomena, we have investigated a series of cyclic analogues. Tertiary amines of structural types 9, 10, 20 and 21 were synthesised and evaluated for mast cell stabilising activity. In vitro and in vivo studies showed that of these compounds, the cyclohexenylamino derivatives of tetralone and benzosuberone of series 20 and 21 exhibited interesting activity both in vitro and in vivo.

DOI

https://doi.org/10.2174/157340611795564222

Recommended Citation

Barlow, J.W., Zhang, T., Woods, O., Byrne, A.J. and Walsh, J.J. (2011). Novel mast cell-stabilising amine derivatives of 3,4 dihydronaphthalen-1(2H)-one and 6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one. Medicinal Chemistry, 7, 213-223. doi:10.2174/157340611795564222

Funder

Enterprise Ireland