Document Type

Conference Paper

Publication Details

https://doi.org/10.1117/12.3022363

Abstract

Clinical pathological diagnosis and prognosis for cancer is often confounded by spatial tissue heterogeneity. This study investigates the utility of entropy as a robust quantitative metric of spatial disorder within Fourier Transform Infrared (FTIR) chemical images of breast cancer tissue. The use of entropy is grounded in its capacity to encapsulate the complexities of pixel-wise spectral intensity distributions, thus providing a detailed assessment of the spatial variations in biochemistry within tissue samples. Here we explore the use of Shannon's entropy as a single image-based metric of spectral biochemical heterogeneity within FTIR chemical images of breast cancer tissue. This metric was then analyzed statistically with respect to hormone receptor status. Our results suggest that while entropy effectively captures the heterogeneity of tissue samples, its role as a standalone predictor for diagnostic subtyping may be limited without considering additional variables or interaction effects. This work emphasizes the need for a multifaceted approach in leveraging entropy with chemical imaging for diagnostic subtyping in cancer.

DOI

10.1117/12.3022363

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

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