Document Type
Article
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
Ophthalmology
Abstract
Purpose:At the macula, the carotenoids meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z) are collectively referred to as macular pigment (MP). This study was designed to measure serum and macular responses to a macular carotenoid formulation. Materials and Methods:Ten subjects were recruited into this study (five normal and five with early age-related macular degeneration [AMD]). Subjects were instructed to consume a formulation containing 7.3mg of MZ, 3.7mg of L, and 0.8mg of Z everyday over an eight-week period. The spatial profile of MP optical density (i.e., MPOD at 0.25°, 0.5°, 1°, and 1.75°) was measured using customized heterochromatic flicker photometry, and a blood sample was collected at each study visit in order to analyze serum concentrations of MZ, L, and Z. Results:There was a significant increase in serum concentrations of MZ and L after two weeks of supplementation (p
DOI
https://doi.org/10.3109/02713680903521951
Recommended Citation
Connolly, E., Beatty, S., Thurnham, D., Loughman, J., Howard, A., Stack, J., Nolan, J.: Augmentation of Macular Pigment Following Supplementation with All Three Macular Carotenoids: An Exploratory Study. Current Eye Research, Vol. 35, No. 4, pp. 335-351. April 2010. doi:10.3109/02713680903521951
Funder
Howard Foundation, Cambridge, United Kingdom
Publication Details
Current Eye Research, Apr 2010, Vol. 35, No. 4, Pages 335-351 (doi: 10.3109/02713680903521951)