Size Dependent Translocation and Fetal Accumulation of Gold Nanoparticles from Maternal Blood in the Rat

Authors

Manuela Semmler-Behnke, Institute of Lung Biology and Disease, Munich, GermanyFollow
Jens Lipka, Institute of Lung Biology and Disease, Munich, GermanyFollow
Alexander Wenk, Institute of Lung Biology and Disease, Munich, GermanyFollow
Martin Schaeffer, Institute of Lung Biology and Disease, Munich, GermanyFollow
Furong Tian, Technological University DublinFollow
Gunter Schmid, Institute of Inorganic Chemistry University Duisburg-Essen 45117 Essen, GermanyFollow
Gunter Oberdorster, Department of Environmental Medicine, University of Rochester, Rochester, New York, USAFollow
Wolfgang Kreyling, Institute of Lung Biology and Disease, Munich, GermanyFollow

Document Type

Article

Rights

Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Publication Details

Particle and Fibre Toxicology 2014, 11:33

Abstract

There is evidence that nanoparticles (NP) cross epithelial and endothelial body barriers. We hypothesized that gold (Au) NP, once in the blood circulation of pregnant rats, will cross the placental barrier during pregnancy size-dependently and accumulate in the fetal organism by 1. transcellular transport across the hemochorial placenta, 2. transcellular transport across amniotic membranes 3. transport through ~20 nm wide transtrophoblastic channels in a size dependent manner. The three AuNP sizes used to test this hypothesis are either well below, or of similar size or well above the diameters of the transtrophoblastic channels.

Recommended Citation

Semmler-Behnke, M. et al. (2014) Size dependent translocation and fetal accumulation of gold nanoparticles from maternal blood in the rat. Particle and Fibre Toxicology 2014, 11:33 doi:10.1186/s12989-014-0033-9