Document Type
Article
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
Inorganic and nuclear chemistry
Abstract
Dinuclear CuII and MnII bis-phenanthroline octanedioate complexes exhibit rapid, unprecedented nano and picomolar in vitro cytotoxicity against colorectal cancer lines and are less toxic than cisplatin when examined in vivo. The complexes are potent generators of cellular reactive oxygen species, avid DNA binders and induce O2 dependent cleavage of DNA. The Cu(II) complex was found to have self-cleaving nuclease activity.
DOI
https://doi.org/10.1039/c0md00266f
Recommended Citation
Kellett, A., O'Connor, M., McCann, M., Howe, O., Casey, A., McCarron, P., Kavanagh, K., McNamara, M., Kennedy, S., May, D., Skell, P., O'Shea, D., Devereux, M.: Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development Medicinal Chemistry Communications, 2, pp.579-584. 2011. doi:10.1039/c0md00266f
Funder
Technological University Dublin, Higher Education Authority
Publication Details
Medicinal Chemistry Communications 2011, 2, pp.579-584
DOI: 10.1039/C0MD00266F