Author ORCID Identifier
https://orcid.org/0000-0001-7113-5111
Document Type
Review
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
1.6 BIOLOGICAL SCIENCES
Abstract
Background
The dynamics of the cellular glycolysis pathway underpin cellular function and dysfunction, and therefore ultimately health, disease, diagnostic and therapeutic strategies. Evolving our understanding of this fundamental process and its dynamics remains critical.
Scope of review
This paper reviews the medical relevance of glycolytic pathway in depth and explores the current state of the art for monitoring and modelling the dynamics of the process. The future perspectives of label free, vibrational microspectroscopic techniques to overcome the limitations of the current approaches are considered.
Major conclusions
Vibrational microspectroscopic techniques can potentially operate in the niche area of limitations of other omics technologies for non-destructive, real-time, in vivo label-free monitoring of glycolysis dynamics at a cellular and subcellular level.
DOI
https://doi.org/10.1016/j.molmet.2022.101635
Recommended Citation
Nitin Patil, Orla Howe, Paul Cahill, Hugh J. Byrne, Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives, Molecular Metabolism, Volume 66, 2022, 101635, ISSN 2212-8778, DOI: 10.1016/j.molmet.2022.101635.
Publication Details
Molecular Metabolism, Elsevier
Open access
https://www.sciencedirect.com/science/article/pii/S2212877822002046?via%3Dihub