Document Type
Article
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
Physical chemistry
Abstract
A novel folic acid–b-cyclodextrin (b-CD) conjugate was synthesized and preliminarily characterized by 1H NMR, ESI-MS, and MALDI-MS. 1H NMR shows the presence of a- and c-conjugates which are generated by b-CD linkage in turn with both carboxylic functions of folic acid. Moreover ROESY evidences supramolecular interactions between the benzene ring of the folic acid and the b-CD cavity. DOSY suggests that ethylenediamine derived b-CD–folic acid forms a colloidal dispersion difficult to purify from free folic acid. An analysis of self-diffusion coefficient (Ds) of the three species (a-, c-conjugates, and free folic acid) and relaxation times (T1 and T2) is reported to tentatively explain the colloidal behaviour of the new species in an aqueous solution.
DOI
https://doi.org/10.1007/s10847-010-9738-z
Recommended Citation
Clementi, A., Aversa, M., Corsaro, C., Spooren, J., Stancanelli, R., O'Connor, C., McNamara, M., Mazzaglia, A.: Synthesis and Characterization of a Colloidal Novel Folic Acid–β-cyclodextrin Conjugate for Targeted Drug Delivery. Journal of Inclusion Phenomena and Macrocyclic Chemistry, Volume 69, Numbers 3-4, pp. 321-325(5). April, 2011. doi:10.1007/s10847-010-9738-z
Publication Details
Journal of Inclusion Phenomena and Macrocyclic Chemistry, Volume 69, Numbers 3-4, April 2011 , pp. 321-325(5)