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1.4 CHEMICAL SCIENCES, 1.6 BIOLOGICAL SCIENCES, Biochemistry and molecular biology, Biophysics, 3. MEDICAL AND HEALTH SCIENCES
A series of complexes incorporating Zn(II), Cu(II), and Pd(II) ions, and 4-(5-heptyl-1,3,4-thiadiazol-2-yl)benzene-1,3-diol (L1) as model ligand, was synthesized in order to examine the nature of potential interactions between biologically active ligands, 1,3,4-thiadiazoles and metal ions with proven biological relevance. The structures of the compounds isolated were characterized using a number of spectroscopic methods including IR, Uv–vis, AAS, steady state and time-resolved fluorescence (TRF). The results obtained suggest that the L1-Zn(II) and L1-Pd(II) complexes consist of one molecule of L1 and one acetate ion acting as ligands, while the L1-Cu(II) complex adapts a 2:1 (L1: metal) stoichiometry. The coordination of L1 to metal ions occurs most likely via one of the deprotonated hydroxyl groups of the resorcinyl moiety and one of the N atoms of the thiadiazole heterocycle.
Dariusz Karcz, Arkadiusz Matwijczuk, Bożena Boroń, Bernadette Creaven, Leszek Fiedor, Andrzej Niewiadomy, Mariusz Gagoś, Isolation and spectroscopic characterization of Zn(II), Cu(II), and Pd(II) complexes of 1,3,4-thiadiazole-derived ligand, Journal of Molecular Structure, Volume 1128, 2017, Pages 44-50, ISSN 0022-2860, DOI: 10.1016/j.molstruc.2016.08.042.