In-Flow dynamics of an area-difference-energy spring-particle red blood cell model on non-uniform grids

Authors

Brendan Walsh, Technological University DublinFollow
Fergal Boyle, Technological University DublinFollow

Author ORCID Identifier

https://orcid.org/0000-0001-6675-8162

Document Type

Article

Rights

Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Disciplines

2.3 MECHANICAL ENGINEERING, Medical engineering

Publication Details

Open access

https://www.tandfonline.com/doi/full/10.1080/10255842.2021.1931845

Abstract

In this paper the area-difference-energy spring-particle (ADE-SP) red blood cell (RBC) structural model developed by Chen and Boyle is coupled with a lattice Boltzmann flux solver to simulate RBC dynamics. The novel ADE-SP model accounts for bending resistance due to the membrane area difference of RBCs while the lattice Boltzmann flux solver offers reduced computational runtimes through GPU parallelisation and enabling the employment of non-uniform meshes. This coupled model is used to simulate RBC dynamics and predictions are compared with existing experimental measurements. The simulations successfully predict tumbling, tank-treading, swinging and intermittent behaviour of an RBC in shear flow, and demonstrate the capability of the model in capturing in-flow RBC behaviours.

DOI

https://doi.org/10.1080/10255842.2021.1931845

Recommended Citation

Dr. Brendan Walsh & Prof. Fergal J. Boyle (2022) In-Flow dynamics of an area-difference-energy spring-particle red blood cell model on non-uniform grids, Computer Methods in Biomechanics and Biomedical Engineering, 25:1, 52-64, DOI: 10.1080/10255842.2021.1931845

Funder

Technological University Dublin