Author ORCID Identifier
https://orcid.org/0000-0003-0962-3434
Document Type
Article
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
Cell biology,, Biochemistry and molecular biology, Medical engineering, Toxicology
Abstract
Ultrasound is a sound wave with frequencies ranging between 20 kHz and 20 MHz. Ultrasound is able to temporarily and repeatedly open the BBB safely and enhance chemotherapeutic delivery without adverse effects. This novel technique in drug delivery benefits from the powerful ability of ultrasound to produce cavitation activity. Cavitation is the generation and activity of gas-filled bubbles in a medium exposed to ultrasound. As the pressure wave passes through the media, gas bubbles expand at low pressure and contract at high pressure. This leads to oscillation which produces a circulating fluid flow known as microstreaming around the bubble with velocities and shear rates proportional to the amplitude of the oscillation. At high amplitudes the associated shear forces can cut open liposomes
DOI
https://dx.doi.org/10.17504/protocols.io.b3udqns6
Recommended Citation
Aisling Field, Brijesh Tiwari, James F Curtin, Julie Rose Mae Mondala, Janith Wanigasekara 2022. Ultrasound 96 Probe Device Protocol for cancer cell treatment. protocols.io. DOI: 10.17504/protocols.io.b3udqns6
Funder
Science Foundation Ireland (SFI)
Included in
Biochemistry Commons, Cancer Biology Commons, Cell Biology Commons, Medical Biochemistry Commons, Medical Biophysics Commons
Publication Details
protocols.io
https://www.protocols.io/view/ultrasound-96-probe-device-protocol-for-cancer-cel-81wgb6pbylpk/v1