Authors
Ali K. Yetisen, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, USA
Haider Butt, School of Mechanical Engineering, University of Birmingham, Birmingham, United Kingdom
Lisa R Volpatti, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
Ida Pavlichenko, School of Engineering and Applied Sciences, Harvard University, Cambridge, USA
Matjaž Humar, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, USA
Sheldon J.J.Kwok Sheldon J.J.Kwok, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, USA
Heebeom Koo, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, USA
Ki Su Kim, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, USA
Izabela Naydenova, Technological University DublinFollow
Ali Khademhosseini, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, USA
Sei Kwang Hahnk, Department of Materials Science & Engineering, Pohang University of Science and Technology (POSTECH), Republic of Korea
Seok Hyun Yunaf, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, USA
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
3.4 HEALTH BIOTECHNOLOGY
Abstract
Analyte-sensitive hydrogels that incorporate optical structures have emerged as sensing platforms for point-of-care diagnostics. The optical properties of the hydrogel sensors can be rationally designed and fabricated through self-assembly, microfabrication or laser writing. The advantages of photonic hydrogel sensors over conventional assay formats include label-free, quantitative, reusable, and continuous measurement capability that can be integrated with equipment-free text or image display. This Review explains the operation principles of photonic hydrogel sensors, presents syntheses of stimuli-responsive polymers, and provides an overview of qualitative and quantitative readout technologies. Applications in clinical samples are discussed, and potential future directions are identified.
DOI
https://doi.org/10.1016/j.biotechadv.2015.10.005
Recommended Citation
Yetisen, A.K., Butt, H. & Volpatt, L.R. (2016). Photonic hydrogel sensors. Biotechnology Advances, vol. 34, no. pg. 250-271.
doi:10.1016/j.biotechadv.2015.10.005
