Document Type

Article

Rights

Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Disciplines

Polymer science, Colloid chemistry, Microbiology

Publication Details

Journal of Colloid and Interface Science 345 (2010) 286–292 doi:10.1016/j.jcis.2010.02.009

Abstract

Coatings that demonstrate reduced attachment of crystalline precipitates and the medical device colonising Staphylococcus epidermidis were prepared by the immobilisation of silver doped perfluoropolyether–urethane siloxane thin films on glass substrates. The presence of stratified hydrophobic perfluoropolyether groups protects the coating surface from the attachment of crystalline hydrophilic species such as chlorides and phosphates, whilst silver ion release inhibited attachment of S. epidermidis and subsequent biofilm formation in vitro. The release of silver ions protects the perfluoro groups from the hydrophobic interactions of S. epidermidis cells, which can reduce the hydrophobicity of the protective coating. These coatings also exhibited significant antibacterial activity against planktonic Acinetobacter baumannii and S. epidermidis bacterial strains. Detailed elemental and chemical surface analysis obtained using X-ray photoelectron spectroscopy (XPS) provided useful information on the effect of bacterial incubation on key indicator hydrophobic and hydrophilic functional groups. XPS analysis indicated preferential adsorption of S. epidermidis cells at the hydrophobic sites along the polymeric chain. These dual-action hygienic coatings can be employed to protect against contamination environmental surfaces and bacterial colonisation on implanted medical devices.

DOI

https://doi.org/10.1016/j.jcis.2010.02.009

Funder

Applied Research Enhancement Programme (AREP) through Enterprise Ireland.

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