Author ORCID Identifier
Document Type
Book Chapter
Disciplines
Atomic, Molecular and Chemical Physics, Analytical chemistry, Biophysics, the onset of disease and maintenance of well-being
Abstract
Histopathology is currently regarded as the “gold standard” patient sampling technique for cancer diagnostics. It involves extraction of a tissue sample, or biopsy, which is then sectioned and stained for evaluation by a pathologist [1]. Cytopathology, on the other hand, is the field of disease diagnosis at the cellular level [2], necessitating only the microscopic evaluation of samples of cells which can be harvested by less invasive methods such as exfoliative brushing, needle probes or from biofluids. Based on the identification of abnormalities in cellular appearance, cytopathology is currently widely used to aid in the screening of cancer, as well as for the diagnosis of some infectious diseases and other inflammatory conditions. Although highly specific, the methodology is notoriously low in sensitivity, however, which can potentially be addressed through emerging more chemically sensitive analysis techniques [3–5].
DOI
https://doi.org/10.1142/9789811264610_0012
Recommended Citation
Lyng, Fiona; Traynor, Damian; Behl, Isha; O'Dea, Declan; and Byrne, Hugh, "Raman Spectral Cytopathology for Cancer Diagnostic Applications" (2023). Books/Book Chapters. 2.
https://arrow.tudublin.ie/biophonbk/2
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Included in
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Publication Details
https://www.worldscientific.com/doi/10.1142/9789811264610_0012?srsltid=AfmBOor_3x2YxnE9SWsL1GZ7y4QZNs0jjzPe8k3ViTlhamlkwcbvXRd4
doi:10.1142/9789811264610_0012