Macular Pigment Levels Increase Following Blue-light Filtering Intraocular Lens Implantation

James Loughman, Dublin Institute of Technology

Document Type Conference Paper

Association for Research in Vision and Ophthalmology, ARVO Florida, 2009.


Purpose:Photo-oxidative stress is believed to play a role in AMD pathogenesis. Macular pigment (MP), consisting of lutein (L), zeaxanthin (Z) and meso-Z, has a max absorption at 460nm and protects the retina from photo-oxidative injury. We investigated whether the blue light filtering properties of the Alcon AcrySof Natural intraocular lens (ANIOL) implanted during cataract surgery impacts on MP optical density (MPOD). Methods:44 patients scheduled for cataract surgery were recruited. All patients had pre-op best corrected visual acuity (BCVA) of at least 0.5logMAR in the study eye. Patients were randomised to have either the standard Alcon AcrySof 3-piece acrylic intraocular lens (AIOL) or the ANIOL. Spatial profile of MPOD was measured by customised heterochromatic flicker photometry (cHFP) 1 week pre-op and 1 week post-op, and at 3, 6 and 12 months post-op. Serum concentrations of L and Z were measured at each visit. Results:There was a significant positive correlation between MPOD values at 0.25deg recorded 1 week pre- and post-op in eyes implanted with an AIOL (r=0.915,p