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Organic Chemistry, Physical chemistry
A novel two-step synthetic route was developed and gave the mono-substituted derivative 6-deoxy-6-[(1-(2-amino)ethylamino)folate]-b-cyclodextrin (CDEnFA) with high yield (60 %). Elemental analysis, mass spectrometry, 1H and 13C NMR, FTIR and Raman spectroscopies demonstrated the successful synthesis of the γ isomer only with no evidence of the presence of other isomers or free folic acid. Electronic absorption spectroscopy was used to study the photochemical properties of CDEnFA and showed that in both the solid state and aqueous solution CDEnFA is considerably more photo-stable than free folic acid.
Tofzikovskaya, Z., O'Connor, C. & McNamara, M. (2015). Synthesis, characterisation and photo-stability of a folate-modified β-cyclodextrin as a functional food additive. Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol. 74, no. 1-4, pg. 437-445. doi:10.1007/s10847-012-0139-3