Document Type
Article
Rights
This item is available under a Creative Commons License for non-commercial use only
Disciplines
1.6 BIOLOGICAL SCIENCES
Abstract
Hypercapnic acidosis frequently occurs when patients with acute lung injury are initially ventilated with low tidal volume "protective" strategies. Hypercapnic acidosis per se, in the absence of any change in tidal volume or airway pressure, is protective when instituted before the onset of injury. However, the mechanisms by which hypercapnic acidosis confers this protection are incompletely understood, in particular, the effects on pulmonary oxidative reactions, which are potent mediators of tissue damage, have not been previously examined in vivo.
Recommended Citation
Nichol, A.D., O'Cronin, D.F., & Naughton, F. (2010). Hypercapnic Acidosis Reduces Oxidative Reactions in Endotoxin-Induced Lung Injury. Anesthesiology, vol. 113, pg. 116–125. doi:10.1097/ALN.0b013e3181dfd2fe
DOI
https://doi.or/10.1097/ALN.0b013e3181dfd2fe