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1.6 BIOLOGICAL SCIENCES
Background: Lysine acetylation is a major post-translational modification of proteins.
Results: Human glycine N-acyltransferase-like 2 is regulated by acetylation/deacetylation of lysine 19.
Conclusion: Reversible lysine acetylation is important in regulating the activity and function of human glycine N-acyltransferases.
Significance: Our study links post-translational modification of proteins with the production of lipid signaling molecules, the N-acyl glycines.
Waluk, D., Sucharski, F., Sipos, L., Silberring, J. & Hunt, M. (2012). Reversible Lysine Acetylation Regulates Activity of Human Glycine N-Acyltransferase-like 2 (hGLYATL2): Implications for Production of Glycine-conjugated Signaling Molecules. The Journal of Biological Chemistry, 287(20), pp.16158-16167. doi:10.1074/jbc.M112.347260