Carcinogenesis in Prostate Cancer: The role of Long Non-Coding RNAs

Authors

John Aird, Department of Histopathology and Morbid Anatomy, School of Medicine, Trinity College Dublin, Ireland
Anne-Marie Baird, Department of Histopathology and Morbid Anatomy, School of Medicine, Trinity College Dublin, Ireland
Marvin C.J Lim, Department of Histopathology and Morbid Anatomy, School of Medicine, Trinity College Dublin, Ireland
Ray McDermott, Department of Medical Oncology, St. Vincent's University Hospital, Dublin, Ireland
Stephen P. Finn, Department of Histopathology and Morbid Anatomy, School of Medicine,Trinity College Dublin, Ireland
Steven G. Gray, Department of Clinical Medicine,

Document Type

Article

Rights

Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Disciplines

1.6 BIOLOGICAL SCIENCES

Publication Details

https://www.sciencedirect.com/science/article/pii/S2468054017300355#!

Abstract

LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been reported to play a role in prostate cancer, particularly in regulating the androgen receptor signalling pathway. In this review article, we summarise the role of 34 lncRNAs in prostate cancer with a particular focus on their role in the androgen receptor signalling pathway and the epithelial to mesenchymal transition pathway.

DOI

10.1016/j.ncrna.2018.01.001

Recommended Citation

Aird, J., Baird, A.M. & Lim, M.C.J. (2018). Carcinogenesis in Prostate Cancer: The role of Long Non-Coding RNAs. Non-coding RNA Research, vol. 3, no. 1, pg. 29-38. doi:10.1016/j.ncrna.2018.01.001