Inverse Relationship Between Physical Activity, Adiposity and Arterial Stiffness in Healthy Middle-aged Subjects
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Physiology, Cardiac and Cardiovascular systems, Endocrinology and metabolism, Public and environmental health, Sport and fitness sciences
Several obesity related factors are reported to exacerbate premature arterial stiffening, including inactivity and metabolic disarray. The aim of the present study was to investigate the relationship between physical activity, arterial stiffness and adiposity using objective methods. To further explore the role of adiposity in this complex process, obesity associated anthropometric and humoral biomarkers were measured.
Seventy-nine healthy, lifelong non-smoking, subjects were recruited. Habitual physical activity was measured using accelerometry. Arterial stiffness (augmentation index; AIx & pulse wave velocity; PWV), was measured using tonometry. Body composition was estimated using bioimpedence. Adipose associated biomarkers, leptin and adiponectin, were also measured.
Sedentary time was significantly associated with AIx (r=0.38, P
The more time healthy individuals spend being sedentary, the greater their body fat and arterial stiffness. Conversely higher activity levels are associated with reduced body fat and less arterial stiffness.
Mac Ananey, O. et al. Inverse Relationship Between Physical Activity, Adiposity and Arterial Stiffness in Healthy Middle-aged Subjects. Journal of Physical Activity & HealthMarch 2015. doi:10.1123/jpah.2014-0395
Journal of Physical Activity & Health, March 2015.