Synthesis and Antimicrobial Evaluation of Carbohydrate and Polyhydroxylated Non-carbohydrate Fatty Acid Ester and Ether Derivatives

Authors

Aoife Smith, Technological University DublinFollow
Patricia Nobmann, Technological University DublinFollow
Gary Henehan, Technological University DublinFollow
Paula Bourke, Technological University DublinFollow
Julie Dunne, Technological University DublinFollow

Document Type

Article

Rights

Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Publication Details

In Carbohydrate Research, Vol.343, Issue 15, 2008, pp.2557-2566. Available here

doi:10.1016/j.carres.2008.07.012

Abstract

A series of fatty acid ester and ether derivatives have been chemically synthesised based on carbohydrate and non-carbohydrate polyhydroxylated scaffolds. The synthesised compounds, along with their corresponding fatty acid monoglyceride antimicrobials, were evaluated for antimicrobial activity against Staphylococcus aureus and Escherichia coli. Of the derivatives synthesised several of the carbohydrate based compounds have antimicrobial efficacy comparable with commercially available antimicrobials. The results suggest that the nature of the carbohydrate core plays a role in the efficacy of carbohydrate fatty acid derivatives as antimicrobials.

DOI

https://doi.org/10.1016/j.carres.2008.07.012

Recommended Citation

Smith, Aoife et al. (2008) Synthesis and antimicrobial evaluation of carbohydrate and polyhydroxylated non-carbohydrate fatty acid ester and ether derivatives. Carbohydrate Research, Vol.343, Issue 15, 2008, pp.2557-2566.

Funder

Science Foundation Ireland TSR Strand I Grant.