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Inorganic and nuclear chemistry
The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a–2k) in good yields. Subsequent reaction of these ligands with copper( II) acetate yielded Cu(II) complexes (3a–3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity.
Creaven, B. et al. Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity. Journal of Inorganic Biochemistry, 103 (2009) 1196–1203. doi:10.1016/j.jinorgbio.2009.05.017
Technological Sector Research Programme, Strand 1, under the European Social Fund