Document Type
Conference Paper
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
Biochemistry and molecular biology, Medical engineering
Abstract
A crosslinked, multicomponent scaffold of collagen, GAG and fibrin has been characterised for heart valve applications. Fibrin gels reinforced with a 0.75% collagen, 0.044% GAG scaffolds can resist VSMC induced contraction significantly more than fibrin-only gels, while allowing cell proliferation and maintaining excellent cell viability. This improvement in structural integrity may facilitate the use of fibrin based materials for heart valve tissue engineering.
Recommended Citation
Brougham, C., Cooney, G., Jockenhoevel , S., Flanagan, T.C., O'Brien, F.J. : A New Reinforced Fibrin Collagen Glycosaminoglycan Material to Resist Tissue Contraction in Heart Valves, 7th World Congress in Biomechanics, Boston, MA, 2014. DOI: 10.13140/2.1.3886.0165
DOI
https://doi.org/10.13140/2.1.3886.0165
Funder
Irish Heart Foundation
Publication Details
7th World Congress in Biomechanics, Boston, MA, 2014.