Document Type
Article
Disciplines
1.4 CHEMICAL SCIENCES
Abstract
The functional role of collagen piezoelectricity has been under debate since the discovery of piezoelectricity in bone in 1957. The possibility that piezoelectricity plays a role in bone remodelling has generated interest in the investigation of this effect in relevant physiological conditions; however, there are conflicting reports as to whether collagen is piezoelectric in a humid environment. In macroscale measurements, the piezoelectricity in hydrated tendon has been shown to be insignificant compared to dehydrated tendon, whereas, at the nanoscale, the piezoelectric effect has been observed in both dry and wet bone using piezo response force microscopy (PFM). In this work, the electromechanical properties of type I collagen from a rat tail tendon have been investigated at the nanoscale as a function of humidity using lateral PFM (LPFM) for the first time. The relative humidity (RH) was varied from 10% to 70%, allowing the piezoelectric behaviour to be studied dry, humid, as well as in the hydrated range for collagen in physiological bone (12% moisture content, corresponding to 40–50% RH). The results show that collagen piezo response can be measured across the humidity range studied, suggesting that piezoelectricity remains a property of collagen at a biologically relevant humidity.
DOI
https://doi.org/10.3390/ma16176034
Recommended Citation
Bazaid, Arwa; Zhang, Fengyuan; Zhang, Qiancheng; Neumayer, Sabine; Denning, Denise; Habelitz, Stefan; Ferreira, Ana Marina; and Rodriguez, Brian J., "Electromechanical Coupling in Collagen Measured Under Increasing Relative Humidity" (2023). Articles. 228.
https://arrow.tudublin.ie/creaart/228
Funder
This research was funded by the Ministry of Higher Education of Saudi Arabia under King Abdullah Scholarship Program (IR10239), Science Foundation Ireland (SFI) (SFI/14/US/I3113, SFI/17/CDA/4637 (SFI Career Development Award Grant with the Sustainable Energy Authority of Ireland (SEAI)), China Scholarship Council, and the European Union’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement number 644175
Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 International License.
Publication Details
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488372/
Materials (Basel). 2023 Sep; 16(17): 6034. Published online 2023 Sep 2. doi: 10.3390/ma16176034