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Computer Sciences, Bioinformatics, Clinical neurology, Health care sciences and services
Unknown onset time is a common contraindication for anti-thrombolytic treatment of ischaemic stroke. T2 relaxation-based signal changes within the lesion can identify patients within or beyond the 4.5-hour intravenous thrombolysis treatment-window. However, now that intra-arterial thrombolysis is recommended between 4.5 and 6 hours from symptom onset and mechanical thrombectomy is considered safe between 6 and 24 hours, there are three treatment-windows to consider. Here we show a cumulative ordinal regression model, incorporating the T2 relaxation time, predicts the probabilities of a patient being within one of the three treatment-windows and is more accurate than signal intensity changes from T2 weighted images.
McGarry et al. (2021)Stratifying ischaemic stroke patients across 3 treatment windows using T2 relaxation times, ordinal regression and cumulative probabilities, Proceedings from the International Society of Magnetic Resonance in Medicine (ISMRM) Annual Conference; 29: 3265.