Document Type

Theses, Masters


Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Publication Details

MPhil Research Project Technological University Dublin, School of Physics Year of submission May 2017


Objectives: To determine the influence of aging on measured left ventricular (LV) diastolic parameters using healthy subjects aged 40-79 years. To propose age-related reference values for LV filling pressure, LV isovolumic relaxation time (LV IVRT) and myocardial stiffness index for each decade using pulsed waved tissue Doppler.

Background: Pulsed wave tissue Doppler parameters have been used for over a decade in the clinical setting as an aid to the evaluation of diastolic function and filling pressures, however there is limited information on normal reference ranges especially in middle age and the older person.

Methods: Subjects with no known history of cardiovascular disease were selected for this prospective study. All subjects underwent routine 2-dimensional echocardiography and Doppler studies. Pulsed wave tissue Doppler was performed to measure peak S’, E’ and A’ myocardial velocities from both the medial and the lateral mitral annulus. The mean E’ peak velocity was (medial E’ + lateral E’) calculated, and mean E/E’ ratios for the two annular sites were then used as an index of left ventricular filling pressure. The study population was divided into four age decades: 40-49, 50-59, 60-69, 70-79 years. The LV filling pressure, isovolumic relaxation time and stiffness index were analysed for each of the four decades to determine normal reference ranges from middle age to the older person.

Results: One hundred and twenty-one healthy subjects (Male, n = 65) aged 40-79 years were included in this study. LV filling pressure (p = 0.005), LV IVRT (p