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Inorganic and nuclear chemistry
Dinuclear CuII and MnII bis-phenanthroline octanedioate complexes exhibit rapid, unprecedented nano and picomolar in vitro cytotoxicity against colorectal cancer lines and are less toxic than cisplatin when examined in vivo. The complexes are potent generators of cellular reactive oxygen species, avid DNA binders and induce O2 dependent cleavage of DNA. The Cu(II) complex was found to have self-cleaving nuclease activity.
Kellett, A., O'Connor, M., McCann, M., Howe, O., Casey, A., McCarron, P., Kavanagh, K., McNamara, M., Kennedy, S., May, D., Skell, P., O'Shea, D., Devereux, M.: Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development Medicinal Chemistry Communications, 2, pp.579-584. 2011. doi:10.1039/c0md00266f