Title

Water-soluble bis(1,10-phenanthroline) Octanedioate Cu2+ and Mn2+ Complexes with Unprecedented Nano and Picomolar in Vitro Cytotoxicity: Promising Leads for Chemotherapeutic Drug Development

Authors

Andrew Kellett, Technological University Dublin
Mark O'Connor, Technological University Dublin
Malachy McCann, National University of Ireland, Maynooth
Orla Howe, Technological University DublinFollow
Alan Casey, Technological University DublinFollow
Pauric McCarron, Dublin I
Kevin Kavanagh, National University of Ireland, Maynooth
Mary McNamara, Technological University DublinFollow
Sean Kennedy, Technological University Dublin
Donald May, E.I. Dupont de Nemours Co
Philip Skell, Pennsylvania State University
Denis O'Shea, Technological University Dublin
Michael Devereux, Technological University DublinFollow

Document Type

Article

Rights

This item is available under a Creative Commons License for non-commercial use only

Disciplines

Inorganic and nuclear chemistry

Publication Details

Medicinal Chemistry Communications 2011, 2, pp.579-584

DOI: 10.1039/C0MD00266F

Abstract

Dinuclear Cu^II and Mn^II bis-phenanthroline octanedioate complexes exhibit rapid, unprecedented nano and picomolar in vitro cytotoxicity against colorectal cancer lines and are less toxic than cisplatin when examined in vivo. The complexes are potent generators of cellular reactive oxygen species, avid DNA binders and induce O₂ dependent cleavage of DNA. The Cu(II) complex was found to have self-cleaving nuclease activity.

Recommended Citation

Kellett, A., O'Connor, M., McCann, M., Howe, O., Casey, A., McCarron, P., Kavanagh, K., McNamara, M., Kennedy, S., May, D., Skell, P., O'Shea, D., Devereux, M.: Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development Medicinal Chemistry Communications, 2, pp.579-584. 2011. doi:10.1039/c0md00266f

DOI

https://doi.org/10.1039/c0md00266f