Document Type
Article
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
Organic Chemistry
Abstract
L-Proline derived spirolactams and a-methyl prolinamides act as organocatalysts for the asymmetric conjugate addition of aldehydes to nitroolefins in excellent yields, with good diastereoselectivity and enantioselectivity. Furthermore, low catalyst loadings (5 mol%) and a low aldehyde molar excess (1.5 molar equivalents) were achieved.
Recommended Citation
Kelleher, F., Kelly, S., Watts, J. and McKee, V. Structure-reactivity relationships of L-proline derived spirolactams and a-methyl prolinamide organocatalysts in the asymmetric Michael addition reaction of aldehydes to nitroolefins. Tetrahedron Volume 66, Issue 19, 8 May 2010, Pages 3525–3536. DOI: 10.1016/j.tet.2010.03.002 ...
Funder
Irish Government
Publication Details
Tetrahedron Volume 66, Issue 19, 8 May 2010, Pages 3525–3536.