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This chapter provides a brief overview of molecular imaging techniques and its present and future potential in personalized medicine, with special a focus on the magnetic resonance imaging (MRI) approach. It discusses the current techniques that allow for the in vivo visualization of molecular processes at the nanoscale resolution (nano-MRI). Nano-MRI is progressing rapidly thanks to the work of a very small but extremely brilliant community of experts. This paper is not intended to be a comprehensive review of nano-MRI written for these experts, but rather a concise description of the present achievements for a much broader audience of medical professionals. The goal is to bridge the gap between the nano- MRI community and those in the medical field that will ultimately benefit from the further development of nano-MRI targeting specific medical goals. The aim of this review is to highlight the potential of nano-MRI in the improvement of MRI sensitivity and consequently on the impact of this widely used technique for diagnosis and personalized treatment. Sensitivity improvements are based on the use of magnetic nanoprobes in conventional MRI as well as novel nanoscale imaging based on nitrogen-vacancy (NV) centers in diamonds.
Rossa, L., Blackledge, J & Boretti, A. (2020) Nanomagnetic Resonance Imaging (Nano-MRI) Gives Personalized Medicine a New Perspective in (Eds) Shaker A. Mousa, Raj Bawa, and Gerald F. Audette, The Road from Nanomedicine to Precision Medicine,2020 Jenny Stanford Publishing Pte. Ltd. ISBN 978-981-4800-59-4