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3.4 HEALTH BIOTECHNOLOGY
Analyte-sensitive hydrogels that incorporate optical structures have emerged as sensing platforms for point-of-care diagnostics. The optical properties of the hydrogel sensors can be rationally designed and fabricated through self-assembly, microfabrication or laser writing. The advantages of photonic hydrogel sensors over conventional assay formats include label-free, quantitative, reusable, and continuous measurement capability that can be integrated with equipment-free text or image display. This Review explains the operation principles of photonic hydrogel sensors, presents syntheses of stimuli-responsive polymers, and provides an overview of qualitative and quantitative readout technologies. Applications in clinical samples are discussed, and potential future directions are identified.
Yetisen, A.K., Butt, H. & Volpatt, L.R. (2016). Photonic hydrogel sensors. Biotechnology Advances, vol. 34, no. pg. 250-271. doi:10.1016/j.biotechadv.2015.10.005