Document Type

Book Chapter


Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence


1.3 PHYSICAL SCIENCES, Optics, 1.4 CHEMICAL SCIENCES, Physical chemistry, Analytical chemistry, 1.6 BIOLOGICAL SCIENCES, Biochemistry and molecular biology, Biochemical research methods, Biophysics, 2.10 NANO-TECHNOLOGY, 3. MEDICAL AND HEALTH SCIENCES, Toxicology, 3.2 CLINICAL MEDICINE, Oncology

Publication Details

Book chapter published in “Optical Spectroscopy and Computational Methods in Biology and Medicine”, M. Baranska ed., Springer Series, Challenges and Advances in Computational Chemistry and Physics, (2014) ISBN 978-94-007-7831-3



This chapter outlines some developments in the applications of vibrational spectroscopy for disease diagnostics and demonstrates how the applications of the spectroscopic techniques can be extended to the analysis and evaluation of disease aetiology and the mechanisms of interaction and the cellular and subcellular responses to, for example chemotherapeutic agents and nanoparticles. The primary emphasis is on Raman spectroscopy, although some examples are based on infrared absorption spectroscopy. The studies presented are chosen to illustrate how a range of multivariate analytical techniques can be employed to maximize the potential benefits of the complex spectral information obtained from tissue or cells.