Document Type
Article
Rights
Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence
Disciplines
2.3 MECHANICAL ENGINEERING, Medical engineering
Abstract
The delivery of high-power ultrasonic energy via small diameter wire waveguides represents a new alternative therapy for the treatment of chronic totally occluded arteries (CTOs). This type of energy manifests itself as a mechanical vibration at the distal-tip of the waveguide with amplitudes of vibration up to 60 µm and at frequencies of 20- 50 kHz. Disruption of diseased tissue is reported to be a result of direct mechanical ablation, cavitation, pressure components and acoustic streaming and that ablation was only evident above the cavitation threshold. This work presents a linear finite element acoustic fluid-structure model of an ultrasonic angioplasty waveguide in vivo. The model was first verified against a reported analytical solution for an oscillating sphere. It was determined that 140 elements per wavelength (EPW) were required to predict the pressure profile generated by the wire waveguide distal-tip. Implementing this EPW count, the pressure field surrounding a range of distal-tip geometries was modelled. For validation, a model was developed with parameters based on a bench-top experiment from the literature of an ultrasonic wire waveguide in a phantom leg. This model showed good correlation with the experimental measurements. These models may aid in the further development of this technology.
Recommended Citation
Wylie, M., McGuinness, G., Graham, G. (2010) A Linear Finite element Acoustic Fluid-Structure Model of Ultrasonic Angioplasty in Vivo. International Journal for Numerical Methods in Biomedical Engineering. vol.26, no.7,pp.828–842. doi:10.1002/cnm.1383
DOI
https://doi.org/10.1002/cnm.1383
Funder
HEA Technology Sector Research: Strand I
Publication Details
International Journal for Numerical Methods in Biomedical Engineering, 2010, 26, pp.828-842. Special issue: Selected papers from the First International Conference on Computational and Mathematical Biomedical Engineering, CMBE09, Swansea June 29 - 1 July, 2009 - Part 1 Available from http://www3.interscience.wiley.com/journal/123308619/abstract