MOSAIC Clinical Trial Statistical Analysis Plan Primary Analysis v1.2

Authors

Gareth Lingham, Technological University DublinFollow
Emmanuel Kobia-Acquah, Technological University Dublin
James Loughman, Technological University DublinFollow
Daniel Ian Flitcroft, Technological University DublinFollow

Document Type

Other

Rights

Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Disciplines

3.3 HEALTH SCIENCES

Publication Details

This publication is a statistical analysis plan for the primary 24-month analysis of the Myopia Outcome Study of Atropine in Children (MOSAIC).

Abstract

The Myopia Outcome Study of Atropine Treatment in Children (MOSAIC) is an investigator-led, double-masked randomised controlled trial of nightly atropine 0.01% eye drops compared to nightly placebo eye drops. A previously published protocol paper outlines the rationale, objective and sample size calculation for the study.¹ A total of 250 participants were enrolled in the study and were randomised 2:1 to active treatment and placebo, respectively. This document outlines the plan for analysis of the 24-month outcomes of the MOSAIC.

Recommended Citation

Lingham, Gareth; Kobia-Acquah, Emmanuel; Loughman, James; and Flitcroft, Daniel Ian, "MOSAIC Clinical Trial Statistical Analysis Plan Primary Analysis v1.2" (2022). Other Resources. 3.
https://arrow.tudublin.ie/ceyoth/3

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.